Diverse Humoral Immune Responses in Younger and Older Adult COVID-19 Patients

Jennifer M. Sasson; Joseph J. Campo; Rebecca M. Carpenter; Mary K. Young; Arlo Z. Randall; Krista Trappl-Kimmons; Amit Oberai; Christopher Hung; Joshua Edgar; Andy A. Teng; Jozelyn V. Pablo; Xiaowu Liang; Angela Yee; William A. Petri; David Camerini

doi:10.1128/mBio.01229-21

mBio (Jun 2021)

Diverse Humoral Immune Responses in Younger and Older Adult COVID-19 Patients

Jennifer M. Sasson,
Joseph J. Campo,
Rebecca M. Carpenter,
Mary K. Young,
Arlo Z. Randall,
Krista Trappl-Kimmons,
Amit Oberai,
Christopher Hung,
Joshua Edgar,
Andy A. Teng,
Jozelyn V. Pablo,
Xiaowu Liang,
Angela Yee,
William A. Petri,
David Camerini

Affiliations

Jennifer M. Sasson: Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
Joseph J. Campo: Antigen Discovery, Incorporated, Irvine, California, USA
Rebecca M. Carpenter: Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
Mary K. Young: Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
Arlo Z. Randall: Antigen Discovery, Incorporated, Irvine, California, USA
Krista Trappl-Kimmons: Antigen Discovery, Incorporated, Irvine, California, USA
Amit Oberai: Antigen Discovery, Incorporated, Irvine, California, USA
Christopher Hung: Antigen Discovery, Incorporated, Irvine, California, USA
Joshua Edgar: Antigen Discovery, Incorporated, Irvine, California, USA
Andy A. Teng: Antigen Discovery, Incorporated, Irvine, California, USA
Jozelyn V. Pablo: Antigen Discovery, Incorporated, Irvine, California, USA
Xiaowu Liang: Antigen Discovery, Incorporated, Irvine, California, USA
Angela Yee: Antigen Discovery, Incorporated, Irvine, California, USA
William A. Petri: ORCiD; Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
David Camerini: Antigen Discovery, Incorporated, Irvine, California, USA

DOI: https://doi.org/10.1128/mBio.01229-21
Journal volume & issue: Vol. 12, no. 3

Abstract

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As numerous viral variants continue to emerge in the coronavirus disease 2019 (COVID-19) pandemic, determining antibody reactivity to SARS-CoV-2 epitopes becomes essential in discerning changes in the immune response to infection over time. This study enabled us to identify specific areas of antigenicity within the SARS-CoV-2 proteome, allowing us to detect correlations of epitopes with clinical metadata and immunological signals to gain holistic insight into SARS-CoV-2 infection.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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