mBio
(Jun 2021)
Diverse Humoral Immune Responses in Younger and Older Adult COVID-19 Patients
Jennifer M. Sasson,
Joseph J. Campo,
Rebecca M. Carpenter,
Mary K. Young,
Arlo Z. Randall,
Krista Trappl-Kimmons,
Amit Oberai,
Christopher Hung,
Joshua Edgar,
Andy A. Teng,
Jozelyn V. Pablo,
Xiaowu Liang,
Angela Yee,
William A. Petri,
David Camerini
Affiliations
Jennifer M. Sasson
Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
Joseph J. Campo
Antigen Discovery, Incorporated, Irvine, California, USA
Rebecca M. Carpenter
Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
Mary K. Young
Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
Arlo Z. Randall
Antigen Discovery, Incorporated, Irvine, California, USA
Krista Trappl-Kimmons
Antigen Discovery, Incorporated, Irvine, California, USA
Amit Oberai
Antigen Discovery, Incorporated, Irvine, California, USA
Christopher Hung
Antigen Discovery, Incorporated, Irvine, California, USA
Joshua Edgar
Antigen Discovery, Incorporated, Irvine, California, USA
Andy A. Teng
Antigen Discovery, Incorporated, Irvine, California, USA
Jozelyn V. Pablo
Antigen Discovery, Incorporated, Irvine, California, USA
Xiaowu Liang
Antigen Discovery, Incorporated, Irvine, California, USA
Angela Yee
Antigen Discovery, Incorporated, Irvine, California, USA
William A. Petri
ORCiD Department of Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
David Camerini
Antigen Discovery, Incorporated, Irvine, California, USA
DOI
https://doi.org/10.1128/mBio.01229-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
As numerous viral variants continue to emerge in the coronavirus disease 2019 (COVID-19) pandemic, determining antibody reactivity to SARS-CoV-2 epitopes becomes essential in discerning changes in the immune response to infection over time. This study enabled us to identify specific areas of antigenicity within the SARS-CoV-2 proteome, allowing us to detect correlations of epitopes with clinical metadata and immunological signals to gain holistic insight into SARS-CoV-2 infection.
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