Impact of Urea on Monoclonal Antibodies: Multiple Destabilization and Aggregation Effects for Therapeutic Immunoglobulin G Proteins

• Ji Young Yang,
• Oliver Burkert,
• Boris Mizaikoff,
• Jens Smiatek

Affiliations

Ji Young Yang

Institute for Analytical and Bioanalytical Chemistry, University of Ulm, Ulm, Germany

Oliver Burkert

Analytical Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach (Riss), Germany

Boris Mizaikoff

Institute for Analytical and Bioanalytical Chemistry, University of Ulm, Ulm, Germany

Jens Smiatek

Development NCE, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach (Riss), Germany