Cancer Reports (Oct 2024)

Plasma Profiling of Acute Myeloid Leukemia With Fever‐ and Infection‐Related Complications During Chemotherapy‐Induced Neutropenia

  • Iris C. Kreft,
  • Annemarie van deGeer,
  • Eva R. Smit,
  • Carmen van derZwaan,
  • Floris P. J. vanAlphen,
  • Alexander B. Meijer,
  • Erfan Nur,
  • Arie J. Hoogendijk,
  • Taco W. Kuijpers,
  • Maartje van denBiggelaar

DOI
https://doi.org/10.1002/cnr2.70024
Journal volume & issue
Vol. 7, no. 10
pp. n/a – n/a

Abstract

Read online

ABSTRACT Background Acute myeloid leukemia (AML) is a heterogenous and complex blood cancer requiring aggressive treatment. Early identification and prediction of the complications following treatment is vital for effective disease management. Aims We explored associations between plasma protein levels and fever‐ and infection‐related complications in 26 AML patients during chemotherapy‐induced neutropenia. Material and Methods Longitudinal plasma profiling was conducted using data‐dependent mass spectrometry analysis. Results Mass spectrometry‐based plasma profiling data correlated well with laboratory parameters, including C‐reactive protein, and revealed a broader inflammation protein network associated with fever‐ and infection‐related complications. Discussion and Conclusion These data indicate the potential of longitudinal plasma profiling in AML patients for identifying and predicting complications that may aid in improved disease monitoring and treatment.

Keywords