Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery

Abstract

In this work, a blend of gelatin A (GA) and polyvinylpyrrolidone (PVP K30) was used for semi-solid 3D printing of bone scaffold for ibuprofen (IBU) delivery. The cross-linking of the obtained scaffold was performed with a 1% glutaraldehyde (GTA) solution, followed by lyophilization. The thermal and mechanical properties, as well as drug release profiles, and drug kinetics of prepared scaffolds were investigated. The cross-linked and lyophilized scaffold has shown good thermal stability, mechanical properties, and prolonged release of IBU following the Fickian diffusion process.

Keywords

• semi-solid extrusion 3d printing
• gelatin-based bone scaffold
• in vitro ibuprofen release and kinetics
• microindentation
• hardness