Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy

Yang Ye; Yang Ye; ZhongPing Ji; Wenli Zhou; Cailing Pu; Ya Li; Ya Li; Chengqin Zhou; Xiuhua Hu; Chao Chen; Yaxun Sun; Yaxun Sun; Qi Huang; Wenjuan Zhang; Yu'e Qian; Hong Ren; Feidan Yu; Chenyang Jiang; Chenyang Jiang; Yankai Mao; Bei Wang; João B. Augusto; João B. Augusto; João B. Augusto; Dongwu Lai; Dongwu Lai; Hongjie Hu; Guo-sheng Fu; Guo-sheng Fu

doi:10.3389/fcvm.2021.758635

Frontiers in Cardiovascular Medicine (Nov 2021)

Mean Scar Entropy by Late Gadolinium Enhancement Cardiac Magnetic Resonance Is Associated With Ventricular Arrhythmias Events in Hypertrophic Cardiomyopathy

Yang Ye,
Yang Ye,
ZhongPing Ji,
Wenli Zhou,
Cailing Pu,
Ya Li,
Ya Li,
Chengqin Zhou,
Xiuhua Hu,
Chao Chen,
Yaxun Sun,
Yaxun Sun,
Qi Huang,
Wenjuan Zhang,
Yu'e Qian,
Hong Ren,
Feidan Yu,
Chenyang Jiang,
Chenyang Jiang,
Yankai Mao,
Bei Wang,
João B. Augusto,
João B. Augusto,
João B. Augusto,
Dongwu Lai,
Dongwu Lai,
Hongjie Hu,
Guo-sheng Fu,
Guo-sheng Fu

Affiliations

Yang Ye: Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Yang Ye: Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China
ZhongPing Ji: Institute of Graphics and Image, School of Computer Science and Technology, Hangzhou Dianzi University, Hangzhou, China
Wenli Zhou: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Cailing Pu: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Ya Li: Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Ya Li: Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China
Chengqin Zhou: Institute of Graphics and Image, School of Computer Science and Technology, Hangzhou Dianzi University, Hangzhou, China
Xiuhua Hu: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Chao Chen: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Yaxun Sun: Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Yaxun Sun: Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China
Qi Huang: Department of Cardiovascular, Zhejiang Integrated Traditional and Western Medicine Hospital (HangZhou Red Cross Hospital), Hangzhou, China
Wenjuan Zhang: Department of Information Technology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Yu'e Qian: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Hong Ren: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Feidan Yu: Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Chenyang Jiang: Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Chenyang Jiang: Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China
Yankai Mao: Department of Cardiac Echocardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Bei Wang: Department of Cardiac Echocardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
João B. Augusto: Department of Cardiology, Hospital Professor Doutor Fernando Fonseca, Lisbon, Portugal
João B. Augusto: Institute of Cardiovascular Science, University College London, London, United Kingdom
João B. Augusto: 0Cardiac Imaging Department, Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom
Dongwu Lai: Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Dongwu Lai: Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China
Hongjie Hu: Institute of Graphics and Image, School of Computer Science and Technology, Hangzhou Dianzi University, Hangzhou, China
Guo-sheng Fu: Department of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China
Guo-sheng Fu: Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Hangzhou, China

DOI: https://doi.org/10.3389/fcvm.2021.758635
Journal volume & issue: Vol. 8

Abstract

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Background: Ventricular arrhythmias are associated with sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM). Previous studies have found the late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) was independently associated with ventricular arrhythmia (VA) in HCM. The risk stratification of VA remains complex and LGE is present in the majority of HCM patients. This study was conducted to determine whether the scar heterogeneity from LGE-derived entropy is associated with the VAs in HCM patients.Materials and Methods: Sixty-eight HCM patients with scarring were retrospectively enrolled and divided into VA (31 patients) and non-VA (37 patients) groups. The left ventricular ejection fraction (LVEF) and percentage of the LGE (% LGE) were evaluated. The scar heterogeneity was quantified by the entropy within the scar and left ventricular (LV) myocardium.Results: Multivariate analyses showed that a higher scar [hazard ratio (HR) 2.682; 95% CI: 1.022–7.037; p = 0.039] was independently associated with VA, after the adjustment for the LVEF, %LGE, LV maximal wall thickness (MWT), and left atrium (LA) diameter.Conclusion: Scar entropy and %LGE are both independent risk indicators of VA. A high scar entropy may indicate an arrhythmogenic scar, an identification of which may have value for the clinical status assessment of VAs in HCM patients.

Published in Frontiers in Cardiovascular Medicine

ISSN: 2297-055X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.frontiersin.org/journals/cardiovascular-medicine

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