npj Parkinson's Disease (Dec 2023)

Genetic risk variants in New Yorkers of Puerto Rican and Dominican Republic heritage with Parkinson’s disease

  • Gabriel Miltenberger-Miltenyi,
  • Roberto A. Ortega,
  • Aloysius Domingo,
  • Rachita Yadav,
  • Ayumi Nishiyama,
  • Deborah Raymond,
  • Viktoriya Katsnelson,
  • Nikita Urval,
  • Matthew Swan,
  • Vicki Shanker,
  • Joan Miravite,
  • Ruth H. Walker,
  • Susan B. Bressman,
  • Laurie J. Ozelius,
  • José C. Cabassa,
  • Rachel Saunders-Pullman

DOI
https://doi.org/10.1038/s41531-023-00599-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 6

Abstract

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Abstract There is a paucity of genetic characterization in people with Parkinson’s disease (PD) of Latino and Afro-Caribbean descent. Screening LRRK2 and GBA variants in 32 New Yorkers of Puerto Rican ethnicity with PD and in 119 non-Hispanic-non-Jewish European PD cases revealed that Puerto Rican participants were more likely to harbor the LRRK2-p.G2019S variant (15.6% vs. 4.2%, respectively). Additionally, whole exome sequencing of twelve Puerto Rican and Dominican PD participants was performed as an exploratory study.