Radioprotective influence on mice DNA of biopolymer complexes from tinder Fomes Fomentarius under ionizing radiation in small doses

Abstract

The effects of similar doses of the values of common external irradiation (0,19 Gy/4hours and 0,24 Gy/6 months) at single-strand DNA breaks and the level of the hydrogen bonds in this molecule in different cell types (lymphocytes, hepatocytes and splenocytes) linear mice CC57W/mv are discussed. Mice were exposed to γ-fields produced by “hot” particles of emergency 4-th Chernobyl Unit containing the same radionuclides in the proportions. The possibility of leveling the radiation effects using complex biopolymers from Fomes fomentarius was shown. The ability of melanin-glucan complex to directly counteract the fragmentation of DNA in a model system with lambda phage this macromolecule oxidation products of benzidine and neutralize mutagenic effect in Salmonella typhimurium strains in the classical Ames test was studied.

Keywords

• ionizing radiation
• acute and chronic effects
• DNA
• fungal biopolymers