Nature Communications (Nov 2021)
A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters
- Phanramphoei N. Frantz,
- Aleksandr Barinov,
- Claude Ruffié,
- Chantal Combredet,
- Valérie Najburg,
- Guilherme Dias de Melo,
- Florence Larrous,
- Lauriane Kergoat,
- Samaporn Teeravechyan,
- Anan Jongkaewwattana,
- Emmanuelle Billon-Denis,
- Jean-Nicolas Tournier,
- Matthieu Prot,
- Laurine Levillayer,
- Laurine Conquet,
- Xavier Montagutelli,
- Magali Tichit,
- David Hardy,
- Priyanka Fernandes,
- Hélène Strick-Marchand,
- James Di Santo,
- Etienne Simon-Lorière,
- Hervé Bourhy,
- Frédéric Tangy
Affiliations
- Phanramphoei N. Frantz
- Institut Pasteur, Université de Paris, Innovation Lab: Vaccines
- Aleksandr Barinov
- Institut Pasteur, Université de Paris, Innovation Lab: Vaccines
- Claude Ruffié
- Institut Pasteur, Université de Paris, Innovation Lab: Vaccines
- Chantal Combredet
- Institut Pasteur, Université de Paris, Innovation Lab: Vaccines
- Valérie Najburg
- Institut Pasteur, Université de Paris, Innovation Lab: Vaccines
- Guilherme Dias de Melo
- Institut Pasteur, Université de Paris, Lyssavirus Epidemiology and Neuropathology Unit
- Florence Larrous
- Institut Pasteur, Université de Paris, Lyssavirus Epidemiology and Neuropathology Unit
- Lauriane Kergoat
- Institut Pasteur, Université de Paris, Lyssavirus Epidemiology and Neuropathology Unit
- Samaporn Teeravechyan
- National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Virology and Cell Technology Laboratory
- Anan Jongkaewwattana
- National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Virology and Cell Technology Laboratory
- Emmanuelle Billon-Denis
- Armed Forces Biomedical Research Institute (IRBA), Microbiology and infectious diseases department
- Jean-Nicolas Tournier
- Armed Forces Biomedical Research Institute (IRBA), Microbiology and infectious diseases department
- Matthieu Prot
- Institut Pasteur, Université de Paris, Evolutionary Genomics of RNA viruses unit
- Laurine Levillayer
- Institut Pasteur, Université de Paris, Evolutionary Genomics of RNA viruses unit
- Laurine Conquet
- Institut Pasteur, Université de Paris, Laboratory of Mouse Genetics
- Xavier Montagutelli
- Institut Pasteur, Université de Paris, Laboratory of Mouse Genetics
- Magali Tichit
- Institut Pasteur, Université de Paris, Experimental Neuropathology unit
- David Hardy
- Institut Pasteur, Université de Paris, Experimental Neuropathology unit
- Priyanka Fernandes
- Institut Pasteur, Université de Paris, INSERM U1223, Innate Immunity unit
- Hélène Strick-Marchand
- Institut Pasteur, Université de Paris, INSERM U1223, Innate Immunity unit
- James Di Santo
- Institut Pasteur, Université de Paris, INSERM U1223, Innate Immunity unit
- Etienne Simon-Lorière
- Institut Pasteur, Université de Paris, Evolutionary Genomics of RNA viruses unit
- Hervé Bourhy
- Institut Pasteur, Université de Paris, Lyssavirus Epidemiology and Neuropathology Unit
- Frédéric Tangy
- Institut Pasteur, Université de Paris, Innovation Lab: Vaccines
- DOI
- https://doi.org/10.1038/s41467-021-26506-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Here the authors generate a measles virus-based vaccine expressing SARSCoV-2 spike protein and show immunogenicity and protection in mice and hamsters, including neutralization of circulating variants of concerns in vitro.
