RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia

Vasily V. Grinev; Farnaz Barneh; Ilya M. Ilyushonak; Sirintra Nakjang; Job Smink; Anita van Oort; Richard Clough; Michael Seyani; Hesta McNeill; Mojgan Reza; Natalia Martinez-Soria; Salam A. Assi; Tatsiana V. Ramanouskaya; Constanze Bonifer; Olaf Heidenreich

doi:10.1038/s41467-020-20848-z

Nature Communications (Jan 2021)

RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia

Vasily V. Grinev,
Farnaz Barneh,
Ilya M. Ilyushonak,
Sirintra Nakjang,
Job Smink,
Anita van Oort,
Richard Clough,
Michael Seyani,
Hesta McNeill,
Mojgan Reza,
Natalia Martinez-Soria,
Salam A. Assi,
Tatsiana V. Ramanouskaya,
Constanze Bonifer,
Olaf Heidenreich

Affiliations

Vasily V. Grinev: Department of Genetics, Faculty of Biology, Belarusian State University
Farnaz Barneh: Princess Maxima Center for Pediatric Oncology
Ilya M. Ilyushonak: Department of Genetics, Faculty of Biology, Belarusian State University
Sirintra Nakjang: Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University
Job Smink: Princess Maxima Center for Pediatric Oncology
Anita van Oort: Princess Maxima Center for Pediatric Oncology
Richard Clough: Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University
Michael Seyani: Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University
Hesta McNeill: Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University
Mojgan Reza: Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University
Natalia Martinez-Soria: Wolfson Childhood Cancer Research Centre, Translational and Clinical Research Institute, Newcastle University
Salam A. Assi: Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham
Tatsiana V. Ramanouskaya: Department of Genetics, Faculty of Biology, Belarusian State University
Constanze Bonifer: Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham
Olaf Heidenreich: Princess Maxima Center for Pediatric Oncology

DOI: https://doi.org/10.1038/s41467-020-20848-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

Read online

The fusion gene RUNX1/RUNX1T1 is oncogenic in acute myeloid leukemia. Here, the authors show that the fusion gene alters the transcriptional landscape of the cells by changing the structure of the 5’UTR, altering isoform expression, and controlling the expression of splicing factors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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