An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease

Pradipta Ghosh; Gajanan D. Katkar; Chisato Shimizu; Jihoon Kim; Soni Khandelwal; Adriana H. Tremoulet; John T. Kanegaye; Pediatric Emergency Medicine Kawasaki Disease Research Group

doi:10.1038/s41467-022-30357-w

Nature Communications (May 2022)

An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease

Pradipta Ghosh,
Gajanan D. Katkar,
Chisato Shimizu,
Jihoon Kim,
Soni Khandelwal,
Adriana H. Tremoulet,
John T. Kanegaye,
Pediatric Emergency Medicine Kawasaki Disease Research Group

Affiliations

Pradipta Ghosh: Department of Cellular and Molecular Medicine, University of California San Diego
Gajanan D. Katkar: Department of Cellular and Molecular Medicine, University of California San Diego
Chisato Shimizu: Department of Pediatrics, University of California San Diego
Jihoon Kim: Department of Biomedical informatics, University of California San Diego
Soni Khandelwal: Department of Computer Science and Engineering, Jacob’s School of Engineering, University of California San Diego
Adriana H. Tremoulet: Department of Pediatrics, University of California San Diego
John T. Kanegaye: Department of Pediatrics, University of California San Diego
Pediatric Emergency Medicine Kawasaki Disease Research Group

DOI: https://doi.org/10.1038/s41467-022-30357-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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Multisystem inflammatory syndrome may occur in children following COVID-19 infection. Here, the authors analyze gene signatures to show that MIS-C shares the same host immune response as the pre-pandemic inflammatory syndrome of Kawasaki disease but is further along in the spectrum in disease severity

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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