Anti-recoverin antibody positive Heidenhain variant CJD: a case report

Abstract

ABSTRACTThe Heidenhain variant Creutzfeldt-Jakob disease (CJD) is characterized by isolated visual symptoms at disease onset, which may mimic numerous ophthalmological disorders. Anti-recoverin autoantibody can be found in patients with autoimmune-related retinopathies. The presence of this antibody with visual symptoms might be confusing in the early stages of the Heidenhain variant CJD. We describe the first case of an anti-recoverin antibody found in the Heidenhain variant CJD who presented with progressive blurred vision then memory deterioration proceeded later. This presentation reinforces the concept that the presence of the anti-recoverin antibody could not exclude the possibility of the Heidenhain variant of CJD in highly suspicious patients with initial isolated visual disturbance.

Keywords

• Anti-recoverin antibody
• autoimmune-related retinopathies
• Creutzfeldt-Jakob disease (CJD)
• Heidenhain variant CJD
• isolated visual symptoms