Nature Communications (Feb 2017)
Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation
- Gyda Bjornsdottir,
- Stefania Benonisdottir,
- Gardar Sveinbjornsson,
- Unnur Styrkarsdottir,
- Gudmar Thorleifsson,
- G. Bragi Walters,
- Aron Bjornsson,
- Ingvar H. Olafsson,
- Elfar Ulfarsson,
- Arnor Vikingsson,
- Ragnheidur Hansdottir,
- Karl O. Karlsson,
- Thorunn Rafnar,
- Ingileif Jonsdottir,
- Michael L. Frigge,
- Augustine Kong,
- Asmundur Oddsson,
- Gisli Masson,
- Olafur T. Magnusson,
- Tomas Gudbjartsson,
- Hreinn Stefansson,
- Patrick Sulem,
- Daniel Gudbjartsson,
- Unnur Thorsteinsdottir,
- Thorgeir E. Thorgeirsson,
- Kari Stefansson
Affiliations
- Gyda Bjornsdottir
- deCODE Genetics/Amgen, Inc.
- Stefania Benonisdottir
- deCODE Genetics/Amgen, Inc.
- Gardar Sveinbjornsson
- deCODE Genetics/Amgen, Inc.
- Unnur Styrkarsdottir
- deCODE Genetics/Amgen, Inc.
- Gudmar Thorleifsson
- deCODE Genetics/Amgen, Inc.
- G. Bragi Walters
- deCODE Genetics/Amgen, Inc.
- Aron Bjornsson
- Department of Neurosurgery, Landspitali University Hospital
- Ingvar H. Olafsson
- Department of Neurosurgery, Landspitali University Hospital
- Elfar Ulfarsson
- Department of Neurosurgery, Landspitali University Hospital
- Arnor Vikingsson
- Department of Medicine, Landspitali, National University Hospital
- Ragnheidur Hansdottir
- Department of Dentistry, University of Iceland
- Karl O. Karlsson
- Department of Dentistry, University of Iceland
- Thorunn Rafnar
- deCODE Genetics/Amgen, Inc.
- Ingileif Jonsdottir
- deCODE Genetics/Amgen, Inc.
- Michael L. Frigge
- deCODE Genetics/Amgen, Inc.
- Augustine Kong
- deCODE Genetics/Amgen, Inc.
- Asmundur Oddsson
- deCODE Genetics/Amgen, Inc.
- Gisli Masson
- deCODE Genetics/Amgen, Inc.
- Olafur T. Magnusson
- deCODE Genetics/Amgen, Inc.
- Tomas Gudbjartsson
- Faculty of Medicine, University of Iceland
- Hreinn Stefansson
- deCODE Genetics/Amgen, Inc.
- Patrick Sulem
- deCODE Genetics/Amgen, Inc.
- Daniel Gudbjartsson
- deCODE Genetics/Amgen, Inc.
- Unnur Thorsteinsdottir
- deCODE Genetics/Amgen, Inc.
- Thorgeir E. Thorgeirsson
- deCODE Genetics/Amgen, Inc.
- Kari Stefansson
- deCODE Genetics/Amgen, Inc.
- DOI
- https://doi.org/10.1038/ncomms14265
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 8
Abstract
Lumbar disc herniation (LDH) can cause persistent sciatica, and in some cases surgery is required to relieve symptoms. Here, the authors carry out a genome-wide association study using microdiscectomy as an indicator of severe LDH, and find a locus on chromosome 8 associated with this condition.
