Memorias do Instituto Oswaldo Cruz (Jan 1994)

Transmission blocking immunity as observed in a feeder system and serological reactivity to Pfs 48/45 and Pfs230 in field sera

  • W. Roeffen,
  • T. Lensen,
  • B. Mulder,
  • K. Teelen,
  • R. Sauerwein,
  • W. Eling,
  • JHETh Meuwissen,
  • P. Beckers

DOI
https://doi.org/10.1590/S0074-02761994000600004
Journal volume & issue
Vol. 89
pp. 13 – 15

Abstract

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Monoclonal antibodies (mAbs) and human sera from gametocyte carriers were applied in the bio-assay to test for their transmission-blocking capacity. Competition ELISA's have been developed for the detection of natural transmission blocking antibodies. Approximately 55 of the sera blocking in the bio-assay gave positive results in these competition ELISA's.

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