Comparative evaluation of the therapeutic efficacy and the safety of the Tetraderm® cream in comparison with the Triderm® cream in patients with allergic dermatoses, complicated by secondary infection

Abstract

Often allergic dermatoses complicated by a secondary infection. The main causative agents of pustular skin infections are gram-positive cocci. The goals of external therapy are to eliminate the inflammatory reaction and subjective sensations, eliminate secondary bacterial and fungal infections, reduce dry skin and protect against adverse environmental factors. The effectiveness of local therapy is ensured by properly selected dosage forms of drugs. The aim of this study was to conduct a comparative assessment of the therapeutic efficacy and safety of Tetraderm cream and Triderm cream in patients with inflammatory dermatoses with concomitant bacterial and mycotic infections. The study involved 128 patients, depending on the drug used, the patients were divided into 2 groups. Efficacy was assessed by the relative number of patients (%) with the achieved therapeutic success (by index EASI), the relative number of patients (%) with the achieved therapeutic success on the scale of total clinical judgment of a physician relative number of patients (%) with the achieved improvement in the change in dermatology life quality index DLQI, as well as according to the objective methods of investigation. Safety was evaluated on the basis of monitoring and registration of adverse events, data from clinical laboratory tests. Both drugs demonstrated similar therapeutic efficacy and did not differ in any of the efficacy criteria, both in the ITT population and in the PP population, and also proved to be equally safe.

Keywords

• secondy infected allergodermatoses
• atopic dermatitis
• eczema
• topical therapy
• combined drug