Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons

Noriyuki Nakashima; Kie Nakashima; Akiko Taura; Akiko Takaku-Nakashima; Harunori Ohmori; Makoto Takano

doi:10.1038/s41467-020-15917-2

Nature Communications (May 2020)

Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons

Noriyuki Nakashima,
Kie Nakashima,
Akiko Taura,
Akiko Takaku-Nakashima,
Harunori Ohmori,
Makoto Takano

Affiliations

Noriyuki Nakashima: Department of Physiology, Kurume University School of Medicine
Kie Nakashima: Department of Physiology and Neurobiology, Faculty of Medicine, Kyoto University
Akiko Taura: Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University Hospital
Akiko Takaku-Nakashima: Department of Physiology, Kurume University School of Medicine
Harunori Ohmori: Department of Physiology and Neurobiology, Faculty of Medicine, Kyoto University
Makoto Takano: Department of Physiology, Kurume University School of Medicine

DOI: https://doi.org/10.1038/s41467-020-15917-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 18

Abstract

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The physiological role of the olfactory marker protein (OMP) has been elusive. Here, the authors demonstrate that OMP buffers cAMP and modulates cAMP-gated channel activity upon sensory stimulation, maintaining neuronal firing during odour-source searching.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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