Nature Communications (Jan 2021)

Rhythmic glucose metabolism regulates the redox circadian clockwork in human red blood cells

  • Ratnasekhar Ch,
  • Guillaume Rey,
  • Sandipan Ray,
  • Pawan K. Jha,
  • Paul C. Driscoll,
  • Mariana Silva Dos Santos,
  • Dania M. Malik,
  • Radoslaw Lach,
  • Aalim M. Weljie,
  • James I. MacRae,
  • Utham K. Valekunja,
  • Akhilesh B. Reddy

DOI
https://doi.org/10.1038/s41467-020-20479-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Red blood cells, which do not possess a nucleus, have circadian redox rhythms with incompletely understood regulatory mechanisms. Here the authors show that glucose metabolism plays a crucial role in regulating circadian redox status of human red blood cells.