Nature Communications (Mar 2020)
OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation
- Bernd Schöpf,
- Hansi Weissensteiner,
- Georg Schäfer,
- Federica Fazzini,
- Pornpimol Charoentong,
- Andreas Naschberger,
- Bernhard Rupp,
- Liane Fendt,
- Valesca Bukur,
- Irina Giese,
- Patrick Sorn,
- Ana Carolina Sant’Anna-Silva,
- Javier Iglesias-Gonzalez,
- Ugur Sahin,
- Florian Kronenberg,
- Erich Gnaiger,
- Helmut Klocker
Affiliations
- Bernd Schöpf
- Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University Innsbruck, Schöpfstraße 41
- Hansi Weissensteiner
- Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University Innsbruck, Schöpfstraße 41
- Georg Schäfer
- Institute of Pathology, Neuropathology and Molecular Pathology, Medical University Innsbruck, Müllerstraße 44
- Federica Fazzini
- Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University Innsbruck, Schöpfstraße 41
- Pornpimol Charoentong
- Department of Medical Oncology, National Center for Tumor Diseases, University Hospital and German Cancer Research Center (DKFZ) Heidelberg, Im Neuenheimer Feld 267
- Andreas Naschberger
- Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University Innsbruck, Schöpfstraße 41
- Bernhard Rupp
- Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University Innsbruck, Schöpfstraße 41
- Liane Fendt
- Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University Innsbruck, Schöpfstraße 41
- Valesca Bukur
- TRON, Translationale Onkologie an der Universitätsmedizin der Johannes-Gutenberg-Universität Mainz gGmbH, Freiligrathstraße 12
- Irina Giese
- TRON, Translationale Onkologie an der Universitätsmedizin der Johannes-Gutenberg-Universität Mainz gGmbH, Freiligrathstraße 12
- Patrick Sorn
- TRON, Translationale Onkologie an der Universitätsmedizin der Johannes-Gutenberg-Universität Mainz gGmbH, Freiligrathstraße 12
- Ana Carolina Sant’Anna-Silva
- Department of Visceral, Transplant and Thoracic Surgery, D. Swarovski Research Laboratory, Medical University Innsbruck, Innrain 66/6
- Javier Iglesias-Gonzalez
- Oroboros Instruments GmbH, Schöpfstraße 18
- Ugur Sahin
- TRON, Translationale Onkologie an der Universitätsmedizin der Johannes-Gutenberg-Universität Mainz gGmbH, Freiligrathstraße 12
- Florian Kronenberg
- Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University Innsbruck, Schöpfstraße 41
- Erich Gnaiger
- Department of Visceral, Transplant and Thoracic Surgery, D. Swarovski Research Laboratory, Medical University Innsbruck, Innrain 66/6
- Helmut Klocker
- University Hospital for Urology, Division of Experimental Urology, Department of Surgery, Medical University Innsbruck, Anichstraße 35
- DOI
- https://doi.org/10.1038/s41467-020-15237-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
The re-wiring of the metabolic machinery is a common feature in cancer. Here, the authors show, using paired normal and prostate cancer samples that the cancer samples exhibit a shift to succinate respiration, which is associated with elevated levels of mitochondrial DNA mutations.
