The role of R-loops in transcription-associated DNA double-strand break repair

Abstract

The roles of RNA in the DNA damage response are emerging. We highlight findings from our recent study demonstrating the mechanism for transcription-associated homologous recombination repair (TA-HRR) of DNA double-strand breaks and the critical role of R-loops in TA-HRR.

Keywords

• r-loop
• dna-rna hybrid
• dna double-strand break
• transcription-associated homologous recombination repair
• rad52
• xpg