An electrochemical biosensor based on graphene oxide for determination of sertraline hydrochloride as an antidepressant drug

Abstract

This research was done to develop an electrochemical sensor for the determination of the antidepressant drug sertraline hydrochloride (SH) using carboxylated graphene oxide-modified glassy carbon electrodes and silver vanadate nanoparticles (AgVO3/c-GO/GCE). The modified electrode, made of AgVO3/c-GO nanocomposite, was prepared using a hydrothermal technique. Studying the morphology and structure of changed electrodes revealed that AgVO3 nanowires and c-GO nanosheets formed a 3D hybrid matrix with a significant precise surface area and increased porosity. The prepared AgVO3/c-GO/GCE can be anticipated to be an appropriate platform for selective and sensitive SH sensing, according to studies of the electrochemical properties using CV and DPV techniques. With a detection limit and sensitivity of 25 ± 0.5 nM and 0.01901 μA/μM, respectively, the suggested sensor demonstrated a broad linear response range from concentrations of 0 to 1600 μM. Finally, the design sensor's suitability for accurately and precisely determining the SH in pharmaceutical tablets was assessed.

Keywords

• Sertraline hydrochloride
• Antidepressant Drug
• Silver vanadate nanostructures
• Carboxylated graphene oxide
• Electrochemical Sensor
• Differential Pulse Voltammetry