Communications Biology (Apr 2023)
Mechanism of a rabbit monoclonal antibody broadly neutralizing SARS-CoV-2 variants
- Hangtian Guo,
- Yixuan Yang,
- Tiantian Zhao,
- Yuchi Lu,
- Yan Gao,
- Tinghan Li,
- Hang Xiao,
- Xiaoyu Chu,
- Le Zheng,
- Wanting Li,
- Hao Cheng,
- Haibin Huang,
- Yang Liu,
- Yang Lou,
- Henry C. Nguyen,
- Chao Wu,
- Yuxin Chen,
- Haitao Yang,
- Xiaoyun Ji
Affiliations
- Hangtian Guo
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Yixuan Yang
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Tiantian Zhao
- Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine
- Yuchi Lu
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Yan Gao
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Tinghan Li
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Hang Xiao
- Yurogen Biosystem LLC
- Xiaoyu Chu
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Le Zheng
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- Wanting Li
- Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University
- Hao Cheng
- Yurogen Biosystem LLC
- Haibin Huang
- Yurogen Biosystem LLC
- Yang Liu
- Yurogen Biosystem LLC
- Yang Lou
- Yurogen Biosystem LLC
- Henry C. Nguyen
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Chao Wu
- Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine
- Yuxin Chen
- Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School
- Haitao Yang
- Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University
- Xiaoyun Ji
- The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
- DOI
- https://doi.org/10.1038/s42003-023-04759-5
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 10
Abstract
The molecular mechanism of broad-spectrum neutralization of a rabbit monoclonal antibody 1H1 against Omicron sublineages is revealed by cryo-EM.
