Nature Communications (Apr 2018)

Sign epistasis caused by hierarchy within signalling cascades

  • Philippe Nghe,
  • Manjunatha Kogenaru,
  • Sander J. Tans

DOI
https://doi.org/10.1038/s41467-018-03644-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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Sign epistasis clearly constrains evolution, but its causes are difficult to decipher. Here, the authors study epistasis in a signalling cascade, and arrive at a general criterion and understanding of sign epistasis as arising from the inherent hierarchy between signalling cascade components.