International Journal of General Medicine (Mar 2024)

Predicting Endothelium-Dependent Diastolic Function (FMD) and Its Correlation with the Degree of Coronary Artery Disease (CAD) and Plaque Vulnerability for Cardiovascular Events

  • Zhang G,
  • Yang J,
  • Xing H,
  • Yin H,
  • Gu G

Journal volume & issue
Vol. Volume 17
pp. 1117 – 1125

Abstract

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Guangming Zhang,1 Jing Yang,1 Hanghang Xing,1 Hongning Yin,2 Guoqing Gu1 1Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050004, People’s Republic of China; 2Department of Heart ultrasound, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050004, People’s Republic of ChinaCorrespondence: Guangming Zhang, Department of Cardiology, The Second Hospital of Hebei Medical University, 215, Heping West Road, Shijiazhuang, Hebei, 050004, People’s Republic of China, Tel +86 311-66002999, Email [email protected]: This study aims to investigate the correlation between vascular endothelium-dependent diastolic function (FMD) and the degree of coronary artery disease (CAD), plaque vulnerability, and its predictive value for cardiovascular events.Methods: Initially, patients (n=100) who were admitted from January 2020 to January 2021 and intended to undergo percutaneous coronary intervention (PCI) were selected. Further, FMD in all patients was determined before the procedure and divided into a high-FMD group (≥ 4.2%) and a low-FMD group ( 0.05). Nevertheless, the degree of stenosis of the lesions in the low-FMD group was significantly higher than in the high-FMD group (P < 0.05). In addition, the thickness of the fibrous cap was considerably lower than that in the high-FMD group (P < 0.05). Moreover, the incidence rate of TCFA was significantly higher than the high-FMD group (P < 0.05). The correlation analysis showed that FMD was significantly negatively correlated with the degree of coronary artery lesion stenosis and TCFA (P < 0.05) and positively correlated with the fibrous cap thickness (P < 0.05).Conclusion: Overall, a negative correlation between FMD and the degree of coronary stenosis, plaque vulnerability, and a high predictive value for post-PCI cardiovascular events suggested that FMD could be a critical diagnostic marker for CAD.Keywords: coronary heart disease, endothelium-dependent diastolic function, lesion extent, plaque vulnerability, predictive value

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