Myeloid sarcoma of the small bowel with inversion of chromosome 16: a description of 3 clinical cases

Abstract

Myeloid sarcoma (MS) is a rare malignant solid tumor presented with myeloid blast cells showing varying degrees of maturation. MS may have an extramedullary site, precede, or develop simultaneously with the clinical manifestations of acute myeloid leukemia (AML); it may also occur as an AML relapse. Besides AML, MS may be a manifestation of chronic myeloid leukemia or other chronic myeloproliferative diseases. Due to the fact that this disease is rare, the bulk of the literature on MS is presented with single descriptions of retrospective studies and clinical cases. The paper describes 3 cases of MS with inversion of chromosome 16 and small bowel lesion.

Keywords

• myeloid sarcoma
• granulocytic sarcoma
• chloroma
• acute myeloid leukemia
• inversion of chromosome 16
• high-dose chemotherapy