PdI<sub>2</sub> as a Simple and Efficient Catalyst for the Hydroamination of Arylacetylenes with Anilines
Alessandra Casnati,
Aleksandr Voronov,
Damiano Giuseppe Ferrari,
Raffaella Mancuso,
Bartolo Gabriele,
Elena Motti,
Nicola Della Ca’
Affiliations
Alessandra Casnati
Department of Chemistry, Life Sciences and Environmental Sustainability (SCVSA), University of Parma, Parco Area delle Scienze, 17/A, 43124 Parma, Italy
Aleksandr Voronov
Department of Chemistry, Life Sciences and Environmental Sustainability (SCVSA), University of Parma, Parco Area delle Scienze, 17/A, 43124 Parma, Italy
Damiano Giuseppe Ferrari
Department of Chemistry, Life Sciences and Environmental Sustainability (SCVSA), University of Parma, Parco Area delle Scienze, 17/A, 43124 Parma, Italy
Raffaella Mancuso
Laboratory of Industrial and Synthetic Organic Chemistry (LISOC), Department of Chemistry and Chemical Technologies, University of Calabria, Via P. Bucci 12/C, 87036 Arcavacata di Rende Cosenza, Italy
Bartolo Gabriele
Laboratory of Industrial and Synthetic Organic Chemistry (LISOC), Department of Chemistry and Chemical Technologies, University of Calabria, Via P. Bucci 12/C, 87036 Arcavacata di Rende Cosenza, Italy
Elena Motti
Department of Chemistry, Life Sciences and Environmental Sustainability (SCVSA), University of Parma, Parco Area delle Scienze, 17/A, 43124 Parma, Italy
Nicola Della Ca’
Department of Chemistry, Life Sciences and Environmental Sustainability (SCVSA), University of Parma, Parco Area delle Scienze, 17/A, 43124 Parma, Italy
The hydroamination reaction is a convenient alternative strategy for the formation of C−N bonds. Herein, we report a new versatile and convenient protocol for the hydroamination of arylacetylenes with anilines using palladium iodide in the absence of any added ligand as catalyst. Mild conditions, excellent regio- and stereoselectivity, and high functional group tolerance are the main features of this methodology. A subsequent reduction step gives access to a wide variety of secondary aromatic amines.