New Measles Virus Genotype Associated with Outbreak, China

Emerging Infectious Diseases. 2010;16(6):943-947 DOI 10.3201/eid1606.100089

 

Journal Homepage

Journal Title: Emerging Infectious Diseases

ISSN: 1080-6040 (Print); 1080-6059 (Online)

Publisher: Centers for Disease Control and Prevention

LCC Subject Category: Medicine: Internal medicine: Infectious and parasitic diseases

Country of publisher: United States

Language of fulltext: English

Full-text formats available: PDF, HTML, XML

 

AUTHORS


Leyi Wang

Zhengrong Ding

Huiling Wang

Liqun Li

Yankun Pang

Kevin E. Brown

Songtao Xu

Zhen Zhu

Paul A. Rota

David Featherstone

Ying Deng

EDITORIAL INFORMATION

Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 8 weeks

 

Abstract | Full Text

To determine the origin of the virus associated with a measles outbreak in Menglian County, Yunnan Province, People’s Republic of China, in 2009, we conducted genetic analyses. Phylogenetic analyses based on nucleoprotein (N) and hemagglutinin (H) gene sequences showed that these Menglian viruses were not closely related to sequences of any World Health Organization (WHO) reference strains representing the 23 currently recognized genotypes. The minimum nucleotide divergence between the Menglian viruses and the most closely related reference strain, genotype D7, was 3.3% for the N gene and 3.0% for the H gene. A search of the databases of GenBank, WHO, and the Health Protection Agency Measles Nucleotide Surveillance showed that the Menglian viruses, together with the 2 older non-Menglian viruses, could be members of a new proposed measles genotype, d11. The new genotype designation will allow for better description of measles transmission patterns, especially in the Southeast Asian and Western Pacific regions.