Nature Communications (Aug 2020)

Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination

  • Lars Muhl,
  • Guillem Genové,
  • Stefanos Leptidis,
  • Jianping Liu,
  • Liqun He,
  • Giuseppe Mocci,
  • Ying Sun,
  • Sonja Gustafsson,
  • Byambajav Buyandelger,
  • Indira V. Chivukula,
  • Åsa Segerstolpe,
  • Elisabeth Raschperger,
  • Emil M. Hansson,
  • Johan L. M. Björkegren,
  • Xiao-Rong Peng,
  • Michael Vanlandewijck,
  • Urban Lendahl,
  • Christer Betsholtz

DOI
https://doi.org/10.1038/s41467-020-17740-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

Read online

To define and distinguish fibroblasts from vascular mural cells have remained challenging. Here, using single-cell RNA sequencing and tissue imaging, the authors provide a molecular basis for cell type classification and reveal inter- and intra-organ diversity of these cell types.