Interleukin 33, soluble suppression of tumorigenicity 2, interleukin 27, and galectin 3 as predictors for outcome in patients admitted to intensive care units
Eric Stevan,
Zaric Radica Zivkovic,
Jevdjic Jasna,
Drakulic Svetlana Miletic,
Stanojevic Ivan,
Vojvodic Danilo,
Arsenijevic Petar,
Stojanovic Bojan,
Jakovljevic Stefan,
Markovic Nenad,
Zaric Milan,
Canovic Petar,
Nesic Jelena,
Zornic Nenad
Affiliations
Eric Stevan
Department of Anesthesiology and Reanimation, University Clinical Center Kragujevac, Kragujevac, Serbia
Zaric Radica Zivkovic
Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Jevdjic Jasna
Department of Anesthesiology and Reanimation, University Clinical Center Kragujevac, Kragujevac, Serbia
Drakulic Svetlana Miletic
Department of Neurology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Stanojevic Ivan
Faculty of Medicine of the Military Medical Academy, University of Defense, Belgrade, Serbia
Vojvodic Danilo
Faculty of Medicine of the Military Medical Academy, University of Defense, Belgrade, Serbia
Arsenijevic Petar
Department of Gynecology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Stojanovic Bojan
Department of Surgery, Faculty of Medical Sciences, University Clinical Center Kragujevac, Kragujevac, Serbia
Jakovljevic Stefan
Department of Surgery, Faculty of Medical Sciences, University Clinical Center Kragujevac, Kragujevac, Serbia
Markovic Nenad
Department of Surgery, Faculty of Medical Sciences, University Clinical Center Kragujevac, Kragujevac, Serbia
Zaric Milan
Department of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Canovic Petar
Department of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Nesic Jelena
Department of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Zornic Nenad
Department of Anesthesiology and Reanimation, University Clinical Center Kragujevac, Kragujevac, Serbia
Intensive care units (ICUs) are expert hospital areas that provide treatment and 24 h care for people who are very sick. Sepsis represents a serious, severe condition and it can lead to septic shock and multiple organ dysfunction syndromes and is one of the most common reasons for patients’ hospitalization in ICUs. We wanted to explore the prognostic values of interleukin (IL) 33, soluble suppression of tumorigenicity 2 (sST2), IL 27, and galectin 3 in critically-ill patients. We assumed that these parameters in combination or alone could predict mortality in ICU patients. This research represents a clinical non-randomized prospective study, performed at the Medical Military Academy, a tertiary care hospital in Belgrade, Serbia. The patients were divided in four groups: patients with sepsis (peritonitis, pancreatitis, trauma) and patients without sepsis (trauma). Total number of patients enrolled in the study was 151 and average years of patients were 56.48. The values greater than the cut-off were the predictors of mortality. The IL-33, IL-27 as well as galectin-3 can successfully predict the outcome of critically-ill patients in ICUs. The sST2, cannot predict death in critically-ill patients as a single prognostic factor. However, the combination of at least two biomarkers: IL-33, sST2, IL-27, and galectin-3, gives very significant results in predicting the outcome in patients admitted to ICUs.
