Oil-in-water emulsion adjuvants for pediatric influenza vaccines: a systematic review and meta-analysis

Yu-Ju Lin; Chiao-Ni Wen; Ying-Ying Lin; Wen-Chi Hsieh; Chia-Chen Chang; Yi-Hsuan Chen; Chian-Hui Hsu; Yun-Jui Shih; Chang-Hsun Chen; Chi-Tai Fang

doi:10.1038/s41467-019-14230-x

Nature Communications (Jan 2020)

Oil-in-water emulsion adjuvants for pediatric influenza vaccines: a systematic review and meta-analysis

Yu-Ju Lin,
Chiao-Ni Wen,
Ying-Ying Lin,
Wen-Chi Hsieh,
Chia-Chen Chang,
Yi-Hsuan Chen,
Chian-Hui Hsu,
Yun-Jui Shih,
Chang-Hsun Chen,
Chi-Tai Fang

Affiliations

Yu-Ju Lin: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University
Chiao-Ni Wen: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University
Ying-Ying Lin: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University
Wen-Chi Hsieh: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University
Chia-Chen Chang: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University
Yi-Hsuan Chen: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University
Chian-Hui Hsu: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University
Yun-Jui Shih: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University
Chang-Hsun Chen: Taiwan Centers for Disease Control
Chi-Tai Fang: Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University

DOI: https://doi.org/10.1038/s41467-019-14230-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Here, the authors meta-analyze clinical trials comparing adjuvanted and non-adjuvanted influenza vaccines in children and find that oil-in-water emulsion adjuvant improves the efficacy of inactivated influenza vaccines in healthy immunologically naive children.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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