Nature Communications (Sep 2021)
Genetic and epigenetic basis of hepatoblastoma diversity
- Genta Nagae,
- Shogo Yamamoto,
- Masashi Fujita,
- Takanori Fujita,
- Aya Nonaka,
- Takayoshi Umeda,
- Shiro Fukuda,
- Kenji Tatsuno,
- Kazuhiro Maejima,
- Akimasa Hayashi,
- Sho Kurihara,
- Masato Kojima,
- Tomoro Hishiki,
- Kenichiro Watanabe,
- Kohmei Ida,
- Michihiro Yano,
- Yoko Hiyama,
- Yukichi Tanaka,
- Takeshi Inoue,
- Hiroki Ueda,
- Hidewaki Nakagawa,
- Hiroyuki Aburatani,
- Eiso Hiyama
Affiliations
- Genta Nagae
- Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo
- Shogo Yamamoto
- Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo
- Masashi Fujita
- Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences
- Takanori Fujita
- Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo
- Aya Nonaka
- Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo
- Takayoshi Umeda
- Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo
- Shiro Fukuda
- Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo
- Kenji Tatsuno
- Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo
- Kazuhiro Maejima
- Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences
- Akimasa Hayashi
- Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo
- Sho Kurihara
- Department of Pediatric Surgery, Hiroshima University Hospital
- Masato Kojima
- Department of Pediatric Surgery, Hiroshima University Hospital
- Tomoro Hishiki
- Chiba University Graduate School of Medicine
- Kenichiro Watanabe
- Shizuoka Children’s Hospital
- Kohmei Ida
- Department of Pediatrics, Teikyo University Mizonokuchi Hospital
- Michihiro Yano
- Department of Pediatrics, Akita University Hospital
- Yoko Hiyama
- Department of Biomedical Science, Natural Science Center for Basic Research and Development, Hiroshima University
- Yukichi Tanaka
- Department of Pathology, Kanagawa Children’s Medical Center
- Takeshi Inoue
- Department of Pathology, Osaka City General Hospital
- Hiroki Ueda
- Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo
- Hidewaki Nakagawa
- Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences
- Hiroyuki Aburatani
- Genome Science Laboratory, Research Center for Advanced Science and Technology (RCAST), the University of Tokyo
- Eiso Hiyama
- Department of Pediatric Surgery, Hiroshima University Hospital
- DOI
- https://doi.org/10.1038/s41467-021-25430-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
While hepatoblastoma is the most common pediatric liver cancer, its molecular background has not been fully characterised. Here, the authors perform genomic and epigenomic profiling of 163 untreated pediatric liver tumours and suggest the upregulation of ASCL2 and methylation patterns of IGF2 promoters in driving hepatoblast carcinogenesis.
