Nature Communications (Mar 2016)
Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin
Abstract
The advent of fluorescence-based super-resolution microscopy has created a need for labeling strategies relying on small probes that minimally perturb protein function. Here the authors describe a labeling method that reduces protein tag and label sizes, allowing for accurate protein targeting and measurements of protein dynamics in tight cellular spaces.