Nature Communications (Oct 2022)
HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia
- Qianze Dong,
- Yan Xiu,
- Yang Wang,
- Christina Hodgson,
- Nick Borcherding,
- Craig Jordan,
- Jane Buchanan,
- Eric Taylor,
- Brett Wagner,
- Mariah Leidinger,
- Carol Holman,
- Dennis J. Thiele,
- Sean O’Brien,
- Hai-hui Xue,
- Jinming Zhao,
- Qingchang Li,
- Howard Meyerson,
- Brendan F. Boyce,
- Chen Zhao
Affiliations
- Qianze Dong
- Department of Pathology, Case Western Reserve University
- Yan Xiu
- Department of Pathology, Case Western Reserve University
- Yang Wang
- Department of Pathology, Case Western Reserve University
- Christina Hodgson
- MAWD Pathology Group
- Nick Borcherding
- Department of Pathology and Immunology, Washington University School of Medicine
- Craig Jordan
- Division of Hematology, University of Colorado Anschutz Campus
- Jane Buchanan
- Department of Biochemistry, Carver College of Medicine, University of Iowa
- Eric Taylor
- Department of Biochemistry, Carver College of Medicine, University of Iowa
- Brett Wagner
- Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa
- Mariah Leidinger
- Department of Pathology, University of Iowa
- Carol Holman
- Department of Pathology, University of Iowa
- Dennis J. Thiele
- Sisu Pharma, Inc.
- Sean O’Brien
- Sisu Pharma, Inc.
- Hai-hui Xue
- Center for Discovery and Innovation, Hackensack University Medical Center
- Jinming Zhao
- Department of Pathology, Case Western Reserve University
- Qingchang Li
- Department of Pathology, China Medical University
- Howard Meyerson
- Department of Pathology, University Hospitals Cleveland Medical Center
- Brendan F. Boyce
- Department of Pathology and Laboratory Medicine, University of Rochester Medical Center
- Chen Zhao
- Department of Pathology, Case Western Reserve University
- DOI
- https://doi.org/10.1038/s41467-022-33861-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Acute myeloid leukaemia (AML) is maintained by self-renewing leukemic stem cells. Here the authors show that Heat Shock Transcription Factor 1 (HSF1) is specifically required for the maintenance of AML stem cells, while sparing steady-state and stressed haematopoiesis and that pharmacologically targeting HSF1 may have broad anti-leukemic effects.
