Nature Communications (Feb 2018)
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
- Qirui Wang,
- Zhenqiang He,
- Menggui Huang,
- Tianrun Liu,
- Yanling Wang,
- Haineng Xu,
- Hao Duan,
- Peihong Ma,
- Lin Zhang,
- Scott S. Zamvil,
- Juan Hidalgo,
- Zhenfeng Zhang,
- Donald M. O’Rourke,
- Nadia Dahmane,
- Steven Brem,
- Yonggao Mou,
- Yanqing Gong,
- Yi Fan
Affiliations
- Qirui Wang
- Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine
- Zhenqiang He
- Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine
- Menggui Huang
- Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine
- Tianrun Liu
- Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine
- Yanling Wang
- Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine
- Haineng Xu
- Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine
- Hao Duan
- Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine
- Peihong Ma
- Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine
- Lin Zhang
- Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine
- Scott S. Zamvil
- Department of Neurology and Program in Immunology, University of California at San Francisco
- Juan Hidalgo
- Department of Cellular Biology, Physiology, and Immunology, Autonomous University of Barcelona
- Zhenfeng Zhang
- Department of Radiology The, Second Affiliated Hospital of Guangzhou Medical University
- Donald M. O’Rourke
- Department of Neurosurgery, University of Pennsylvania Perelman School of Medicine
- Nadia Dahmane
- Department of Neurosurgery, University of Pennsylvania Perelman School of Medicine
- Steven Brem
- Department of Neurosurgery, University of Pennsylvania Perelman School of Medicine
- Yonggao Mou
- Department of Neurosurgery, Sun Yat-sen University Cancer Center
- Yanqing Gong
- Department of Medicine, Division of Human Genetics and Translational Medicine, University of Pennsylvania Perelman School of Medicine
- Yi Fan
- Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-03050-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Macrophages in the tumour microenvironment (TME) acquire tumour-promoting functions upon M2 polarization. Here the authors show, in a mouse model of glioblastoma, that endothelial cells in the TME induce macrophage M2 polarization via IL-6 and that depletion of endothelial IL-6 improves survival.
