Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy

Masao Nakayama; Hiroaki Akasaka; Eiichi Miyazaki; Yoshihiro Goto; Yuya Oki; Yosuke Kawate; Kenta Morita; Ryohei Sasaki

Physics and Imaging in Radiation Oncology (Oct 2021)

Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy

Masao Nakayama,
Hiroaki Akasaka,
Eiichi Miyazaki,
Yoshihiro Goto,
Yuya Oki,
Yosuke Kawate,
Kenta Morita,
Ryohei Sasaki

Affiliations

Masao Nakayama: Division of Radiation Therapy, Kita-Harima Medical Center, 926-250 Ichibacho, Ono, Hyogo 675-1392, Japan; Division of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuou-ku, Kobe, Hyogo 650-0017, Japan; Corresponding author at: Division of Radiation Therapy, Kita-Harima Medical Center, 926-250 Ichibacho, Ono, Hyogo 675-1392, Japan.
Hiroaki Akasaka: Division of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuou-ku, Kobe, Hyogo 650-0017, Japan; Division of Radiation Oncology, Kobe Minimally Invasive Cancer Center, 8-5-1 Minatojima-Nakamachi, Chuou-ku, Kobe, Hyogo 650-0046, Japan
Eiichi Miyazaki: Division of Radiation Therapy, Kita-Harima Medical Center, 926-250 Ichibacho, Ono, Hyogo 675-1392, Japan
Yoshihiro Goto: Department of Radiology, Kita-Harima Medical Center, 926-250 Ichibacho, Ono, Hyogo 675-1392, Japan
Yuya Oki: Division of Radiation Oncology, Kobe Minimally Invasive Cancer Center, 8-5-1 Minatojima-Nakamachi, Chuou-ku, Kobe, Hyogo 650-0046, Japan
Yosuke Kawate: Division of Radiation Oncology, Kobe Minimally Invasive Cancer Center, 8-5-1 Minatojima-Nakamachi, Chuou-ku, Kobe, Hyogo 650-0046, Japan
Kenta Morita: Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodaicho, Nada-ku, Kobe, Hyogo 657-8501, Japan
Ryohei Sasaki: Division of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuou-ku, Kobe, Hyogo 650-0017, Japan

Journal volume & issue: Vol. 20
pp. 94 – 97

Abstract

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Metal-based nanoparticles (NPs) have been extensively studied for dose enhancement applications in radiation therapy. This study investigated the utility of such NPs for image-guided radiation therapy (IGRT). Phantom images of gold NPs (AuNPs) and titanium peroxide NPs (TiOxNPs) with different concentrations were acquired using IGRT modalities, including cone-beam computed tomography (CBCT). AuNPs induced strong contrast enhancement in kV energy CBCT images, whereas TiOxNPs at high concentrations showed weak but detectable changes. The results indicated that these NPs can be used to enhance IGRT images as well as dose enhancement for treatment purposes.

Published in Physics and Imaging in Radiation Oncology

ISSN: 2405-6316 (Online)
Publisher: Elsevier
Country of publisher: Ireland
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.journals.elsevier.com/physics-and-imaging-in-radiation-oncology/

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