Nature Communications (Sep 2020)
Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease
- Ke Hou,
- Jing Zhao,
- Hui Wang,
- Bin Li,
- Kexin Li,
- Xinghua Shi,
- Kaiwei Wan,
- Jing Ai,
- Jiawei Lv,
- Dawei Wang,
- Qunxing Huang,
- Huayi Wang,
- Qin Cao,
- Shaoqin Liu,
- Zhiyong Tang
Affiliations
- Ke Hou
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Jing Zhao
- MOE Key Laboratory of Micro-systems and Micro-structures Manufacturing, School of Life Science and Technology, Harbin Institute of Technology
- Hui Wang
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Bin Li
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Kexin Li
- Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, College of Pharmacy of Harbin Medical University
- Xinghua Shi
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Kaiwei Wan
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Jing Ai
- Department of Pharmacology, the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, College of Pharmacy of Harbin Medical University
- Jiawei Lv
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Dawei Wang
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Qunxing Huang
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Huayi Wang
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- Qin Cao
- Department of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute and Howard Hughes Medical Institute, UCLA
- Shaoqin Liu
- MOE Key Laboratory of Micro-systems and Micro-structures Manufacturing, School of Life Science and Technology, Harbin Institute of Technology
- Zhiyong Tang
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology
- DOI
- https://doi.org/10.1038/s41467-020-18525-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Nanoparticles are being explored as a potential method to target Aβ aggregation in Alzheimer’s disease. Here, the authors develop gold nanoparticles that were capped with chiral L or D-glutathione which has been shown to improve BBB permeability and demonstrate their ability to improve cognitive function in a mouse model of AD.
