Thymoglobulin as an induction therapy: protection against ischemia and reperfusion injury

Abstract

Objective: To asses graft function and survival after one year inpatients at high risk of acute tubular necrosis (ATN) and to definethe impact of this lesion on allograft function in patients whoutilized an induction protocol with Thymoglobulin (Thymo).Methods: Thymo was utilized as an induction strategy. CD3+cells counting was monitored. Graft function and survival wasdemonstrated. Results: Seventy-eight patients who receivedkidneys from cadaveric donors utilized the referred protocol.Follow-up was 2 years. Cold ischemia time was 19.9 ± 4.8 hours.Thymo total doses was 7.48 ± 3.7. CD3+ cells counting was19.3 ± 22.3. Acute rejection occurred in 14.1% of cases, ATN in66.6% and CMV infection in 55.1%. One-year graft survival noncensoredby death was 95.9%, and serum creatinine was 1.56 ±0.53 mg/dl. Patients who presented ATN had longer length ofhospital stay (18.8 ± 6.1 vs. 10.4 ± 4.3 days, p 38 years, RR = 3.43, p < 0.001). Conclusion:Thymoglobulin induction provided an excellent graft survival anda low rate of acute rejection and good graft function until 2 yearsafter transplantation, despite high prevalence of ATN.

Keywords

• Kidney tubular necrosis
• acute
• Ischemia
• Reperfusion
• Kidney transplantation
• Antibodies
• monoclonal/therapeutic use