Prevention and management of CMV infection in pediatric solid organ transplant recipients

Shanthi S. Balani; Sanober Sadiq; Chelsey J. Jensen; Sarah J. Kizilbash

doi:10.3389/fped.2023.1098434

Frontiers in Pediatrics (Feb 2023)

Prevention and management of CMV infection in pediatric solid organ transplant recipients

Shanthi S. Balani,
Sanober Sadiq,
Chelsey J. Jensen,
Sarah J. Kizilbash

Affiliations

Shanthi S. Balani: Division of Nephrology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States
Sanober Sadiq: Division of Nephrology, Department of Pediatrics, University of California, San Francisco, CA, United States
Chelsey J. Jensen: Department of Solid Organ Transplant, University of Minnesota, Minneapolis, MN, United States
Sarah J. Kizilbash: Division of Nephrology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States

DOI: https://doi.org/10.3389/fped.2023.1098434
Journal volume & issue: Vol. 11

Abstract

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Human cytomegalovirus (CMV) remains one of the most common opportunistic infections following solid organ transplantation in children. CMV causes morbidity and mortality through direct tissue-invasive disease and indirect immunomodulatory effects. In recent years, several new agents have emerged for the prevention and treatment of CMV disease in solid organ transplant recipients. However, pediatric data remain scarce, and many of the treatments are extrapolated from the adult literature. Controversies exist about the type and duration of prophylactic therapies and the optimal dosing of antiviral agents. This review provides an up-to-date overview of treatment modalities used to prevent and treat CMV disease in solid organ transplant (SOT) recipients.

Published in Frontiers in Pediatrics

ISSN: 2296-2360 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Pediatrics
Website: http://journal.frontiersin.org/journal/pediatrics

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Abstract

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