Efficient Synthesis of a Schiff Base Copper(II) Complex Using a Microfluidic Device
Masashi Kobayashi,
Takashiro Akitsu,
Masahiro Furuya,
Tetsushi Sekiguchi,
Shuichi Shoji,
Takashi Tanii,
Daiki Tanaka
Affiliations
Masashi Kobayashi
Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan
Takashiro Akitsu
Department of Chemistry, Faculty of Science, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan
Masahiro Furuya
Cooperative Major in Nuclear Energy, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1, Okubo, Shinjuku-ku, Tokyo 169-8555, Japan
Tetsushi Sekiguchi
Research Organization for Nano & Life Innovation, Waseda University, 513 Tsurumakicho, Shinjuku-ku, Tokyo 162-0041, Japan
Shuichi Shoji
Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan
Takashi Tanii
Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan
Daiki Tanaka
Research Organization for Nano & Life Innovation, Waseda University, 513 Tsurumakicho, Shinjuku-ku, Tokyo 162-0041, Japan
The efficient synthesis of amino acid Schiff base copper(II) complexes using a microfluidic device was successfully achieved. Schiff bases and their complexes are remarkable compounds due to their high biological activity and catalytic function. Conventionally, products are synthesized under reaction conditions of 40 °C for 4 h using a beaker-based method. However, in this paper, we propose using a microfluidic channel to enable quasi-instantaneous synthesis at room temperature (23 °C). The products were characterized using UV–Vis, FT–IR, and MS spectroscopy. The efficient generation of compounds using microfluidic channels has the potential to significantly contribute to the efficiency of drug discovery and material development due to high reactivity.
