The Evaluation of the Relationship Between Smoking Status and Thiol and Ischemia Modified Albumin Levels of COVID-19 Patients

Abstract

Purpose: Smoking is an important risk factor for both the onset and poor prognosis for respiratory tract infections, chronic obstructive pulmonary disease, and lung cancer. There are no clear data on the relationship of COVID-19 to smoking status. In this study, it is aimed to evaluate the thiol and ischemia modified albumin (IMA) levels of smokers, non-smokers and ex-smokers among COVID-19 patients. Materials and methods: 145 volunteer patients diagnosed with COVID-19 according to PCR test results were included in the study. These patients were divided into three groups as non-smokers (group 1, 49 patients), smokers (group 2, 52 patients), and ex-smokers (group 3, 44 patients). Venous blood samples were taken from the patients into serum tubes for the measurement of thiol and IMA levels. All statistical evaluations were performed using SPSS software program. Results: When the groups were compared, a significant difference was found between the thiol levels of group 1 and group 3, and between group 2 and group 3 (respectively, p=0.021, p=0.008). When the IMA levels were examined, a significant difference was found between the IMA levels of group 1 and group 3, and between group 2 and group 3 (respectively, p=0.009, p=0.005). Conclusion: Smoking disrupts the balance between the oxidant-antioxidant system in the body, this balance is also disrupted in the regeneration process in the body in COVID-19 patients who have quit smoking. In addition, although the relationship between COVID-19 disease and smoking is still controversial, it is undisputed that smoking has harmful effects on all systems in the whole body.

Keywords

• antioxidant
• coronavirüs
• inflammation
• oxidant
• sulfhydry