Case Report: Post-transplant lymphoproliferative disorder as a serious complication of vascularized composite allotransplantation

Alessandra Zaccardelli; Fabienne M. Lucas; Ann S. LaCasce; Anil K. Chandraker; Jamil R. Azzi; Simon G. Talbot

doi:10.3389/frtra.2024.1339898

Frontiers in Transplantation (Mar 2024)

Case Report: Post-transplant lymphoproliferative disorder as a serious complication of vascularized composite allotransplantation

Alessandra Zaccardelli,
Fabienne M. Lucas,
Ann S. LaCasce,
Anil K. Chandraker,
Jamil R. Azzi,
Simon G. Talbot

Affiliations

Alessandra Zaccardelli: Department of Medical Education, Tufts University School of Medicine, Boston, MA, United States
Fabienne M. Lucas: Department of Pathology, Brigham and Women’s Hospital, Boston, MA, United States
Ann S. LaCasce: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States
Anil K. Chandraker: Department of Medicine, Brigham and Women’s Hospital, Boston, MA, United States
Jamil R. Azzi: Department of Medicine, Brigham and Women’s Hospital, Boston, MA, United States
Simon G. Talbot: Division of Plastic and Reconstructive Surgery, Brigham and Women’s Hospital, Boston, MA, United States

DOI: https://doi.org/10.3389/frtra.2024.1339898
Journal volume & issue: Vol. 3

Abstract

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Vascularized composite allotransplantation (VCA) is an emerging field in transplant surgery. Despite overall positive outcomes, VCA confers risk for multiple complications related to the procedure and subsequent immunosuppression. Post-transplant lymphoproliferative disorder (PTLD) is a heterogeneous group of lymphoproliferative disorders occurring after solid organ and hematopoietic stem cell transplant. A patient with PTLD after bilateral upper extremity transplantation is presented as well as a review of all known cases of PTLD after VCA, with a focus on the unique epidemiology, presentation, and treatment in this population.

Published in Frontiers in Transplantation

ISSN: 2813-2440 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine
Website: https://www.frontiersin.org/journals/transplantation

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