Whole-Body Low-Dose Multidetector-Row CT in Multiple Myeloma: Guidance in Performing, Observing, and Interpreting the Imaging Findings
Antonio Pierro,
Alessandro Posa,
Costanzo Astore,
Mariacarmela Sciandra,
Alessandro Tanzilli,
Antonella Petrosino,
Maria Saveria del Balso,
Vincenzo Fraticelli,
Savino Cilla,
Roberto Iezzi
Affiliations
Antonio Pierro
Department of Radiology, “A. Cardarelli” Regional Hospital, ASReM, Contrada Tappino, 86100 Campobasso, Italy
Alessandro Posa
Department of Diagnostic Imaging, Oncologic Radiotherapy and Hematology, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli 8, 00168 Rome, Italy
Costanzo Astore
Radiology Unit, Gemelli Molise Hospital, L.go A. Gemelli 1, 86100 Campobasso, Italy
Mariacarmela Sciandra
Department of Radiology, “A. Cardarelli” Regional Hospital, ASReM, Contrada Tappino, 86100 Campobasso, Italy
Alessandro Tanzilli
Department of Diagnostic Imaging, Oncologic Radiotherapy and Hematology, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli 8, 00168 Rome, Italy
Antonella Petrosino
Department of Diagnostic Imaging, Oncologic Radiotherapy and Hematology, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli 8, 00168 Rome, Italy
Maria Saveria del Balso
Department of Radiology, “A. Cardarelli” Regional Hospital, ASReM, Contrada Tappino, 86100 Campobasso, Italy
Vincenzo Fraticelli
Hematology Unit, Gemelli Molise Hospital, L.go A. Gemelli 1, 86100 Campobasso, Italy
Savino Cilla
Medical Phisics Unit, Gemelli Molise Hospital, L.go A. Gemelli 1, 86100 Campobasso, Italy
Roberto Iezzi
Department of Diagnostic Imaging, Oncologic Radiotherapy and Hematology, Fondazione Policlinico Universitario A. Gemelli IRCCS, L.go A. Gemelli 8, 00168 Rome, Italy
Multiple myeloma is a hematological malignancy of plasma cells usually detected due to various bone abnormalities on imaging and rare extraosseous abnormalities. The traditional approach for disease detection was based on plain radiographs, showing typical lytic lesions. Still, this technique has many limitations in terms of diagnosis and assessment of response to treatment. The new approach to assess osteolytic lesions in patients newly diagnosed with multiple myeloma is based on total-body low-dose CT. The purpose of this paper is to suggest a guide for radiologists in performing and evaluating a total-body low-dose CT in patients with multiple myeloma, both newly-diagnosed and in follow-up (pre and post treatment).
