Impact of Sickle Cell Trait Hemoglobin on the Intraerythrocytic Transcriptional Program of Plasmodium falciparum
Joseph W. Saelens,
Jens E. V. Petersen,
Elizabeth Freedman,
Robert C. Moseley,
Drissa Konaté,
Seidina A. S. Diakité,
Karim Traoré,
Natalie Vance,
Rick M. Fairhurst,
Mahamadou Diakité,
Steven B. Haase,
Steve M. Taylor
Affiliations
Joseph W. Saelens
Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA
Jens E. V. Petersen
Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA
Elizabeth Freedman
Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA
Robert C. Moseley
Department of Biology, Duke University, Durham, North Carolina, USA
Drissa Konaté
Malaria Research and Training Center, Mali International Center for Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali
Seidina A. S. Diakité
Malaria Research and Training Center, Mali International Center for Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali
Karim Traoré
Malaria Research and Training Center, Mali International Center for Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali
Natalie Vance
Duke Global Health Institute, Duke University, Durham, North Carolina, USA
Rick M. Fairhurst
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
Mahamadou Diakité
Malaria Research and Training Center, Mali International Center for Excellence in Research, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali
Steven B. Haase
Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina, USA
Sickle-trait hemoglobin (HbAS) confers nearly complete protection from severe, life-threatening malaria, yet the molecular mechanisms that underlie HbAS protection from severe malaria remain incompletely understood. Here, we used transcriptome sequencing (RNA-seq) to measure the impact of HbAS on the blood-stage transcriptome of Plasmodium falciparumin vitroin vivo
