Nature Communications (Jul 2017)

The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability

  • A. V. Shah,
  • G. M. Birdsey,
  • C. Peghaire,
  • M. E. Pitulescu,
  • N. P. Dufton,
  • Y. Yang,
  • I. Weinberg,
  • L. Osuna Almagro,
  • L. Payne,
  • J. C. Mason,
  • H. Gerhardt,
  • R. H. Adams,
  • A. M. Randi

DOI
https://doi.org/10.1038/ncomms16002
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 16

Abstract

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Vascular maturation and stability is regulated by Notch and Angiopoietin-1/Tie2 signalling. Here, Shahet al. show that the transcription factor ERG coordinates the Ang1, Notch and Wnt/β-catenin pathways to promote vascular maturation and stability.