Attention-deficit hyperkinetic disorder among children and adolescents with type 1 diabetes: a cross-sectional study

Abstract

Abstract Background Type 1 diabetes is a common childhood disease that is affected by and affects every aspect in the life of the child or adolescent with diabetes. Data on attention-deficit hyperkinetic disorder (ADHD) among children and adolescents with type 1 diabetes is limited. The aim of this study was to assess the prevalence of ADHD among a cross-sectional sample of 70 children and adolescents with type 1 diabetes as compared to 70 matched controls and to assess the glycemic control of included patients. For a comprehensive evaluation, assessment was done using Pediatric Symptom Checklist (PSC, the 35 item), Diagnostic and Statistical Manual of Mental Disorders—the fifth edition (DSM-5) criteria, and Conners comprehensive behavior rating scale—revised for parents/caregivers. Glycemic control of all included patients was also evaluated by HbA1c %. Results A screening PSC score was significantly higher for children and adolescents with type 1 diabetes than controls (p < 0.001). Significantly larger number of cases with type 1 diabetes fulfilled DSM-5 criteria for inattentive or hyperactive or mixed type ADHD (14.3%, 17.1% and 18.6%, respectively) as compared to controls (4.3%, 5.7%, and 7.1% respectively, p < 0.05). Also, a significantly larger number (more than half, 57.14%) had a Conners score above 70, and the mean scores on Conners parent rating scale were also significantly higher for children with type 1 diabetes than controls (p < 0.001). Most of the included patients did not achieve adequate glycemic control (47.14% of patients were in poor control and only about one fifth achieved a HbA1c < 7.5%). Conclusion ADHD is more common among children and adolescents with type 1 diabetes than in healthy controls. It is important to perform psychiatric evaluation of children and adolescents with type 1 diabetes especially those in poor metabolic control to assess for associated neuro-behavioral disorders such as ADHD. This is crucial to be able to properly design insulin therapy for such a group of patients who may suffer hypo- or hyper-glycemia due to inattention, forgetfulness, or hyperactivity and to properly select educational material that take the easy distractibility of ADHD patients into account as well as to be able to properly manage such cases given the extra stresses entailed in having a diagnosis of diabetes.

Keywords

• Type 1 diabetes mellitus
• Children and adolescents
• ADHD
• Psychosocial dysfunction
• Glycemic control