Nature Communications (Mar 2018)

GATA3 zinc finger 2 mutations reprogram the breast cancer transcriptional network

  • Motoki Takaku,
  • Sara A. Grimm,
  • John D. Roberts,
  • Kaliopi Chrysovergis,
  • Brian D. Bennett,
  • Page Myers,
  • Lalith Perera,
  • Charles J. Tucker,
  • Charles M. Perou,
  • Paul A. Wade

DOI
https://doi.org/10.1038/s41467-018-03478-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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In breast cancer GATA3 is known to be frequently mutated, but the function of these mutations is unclear. Here, the authors utilise CRISPR-Cas9 to model frame-shift mutations in zinc finger 2 of GATA3, highlighting that GATA3 mutation can have gain- or loss-of function effects in breast cancer.