Larvicidal and Adulticidal Activity of Essential Oils from Four Cuban Plants against Three Mosquito Vector Species
Jesús García-Díaz,
Raimundo Nonato Picanço Souto,
Julio César Escalona-Arranz,
Ricardo Marcelo Dos Anjos Ferreira,
Tiago Silva Da Costa,
Rosalia González-Fernández,
Yamile Heredia-Díaz,
Idelsy Chil-Núñez,
Jorge de la Vega,
Lianet Monzote,
Margareth Maria de Carvalho Queiroz,
William N. Setzer
Affiliations
Jesús García-Díaz
Department of Basic-Biomedical Sciences, Faculty of Nursing-Health Technology, University of Medical Sciences, Carretera del Caney Km 2 1/2, Santiago de Cuba 90100, Cuba
Raimundo Nonato Picanço Souto
Laboratory of Arthropoda, Department of Biology and Health Sciences, Universidade Federal do Amapá, Rodovia Jucelino Kubitschek, Km 02, Macapá 68902-280, AP, Brazil
Julio César Escalona-Arranz
Pharmacy Department, Natural and Exacts Sciences Faculty, Oriente University, Avenida Patricio Lumumba s/n, Santiago de Cuba 90500, Cuba
Ricardo Marcelo Dos Anjos Ferreira
Laboratory of Arthropoda, Department of Biology and Health Sciences, Universidade Federal do Amapá, Rodovia Jucelino Kubitschek, Km 02, Macapá 68902-280, AP, Brazil
Tiago Silva Da Costa
Laboratório de Arthropoda, Universidade Federal do Amapá, Campus Universitário Marco Zero do Equador, Rodovia Juscelino Kubitschek de Oliveira, Km 02, Bairro Zerão, Macapá 68902-280, AP, Brazil
Rosalia González-Fernández
Toxicology and Biomedicine Centre (TOXIMED), University of Medical Science, Autopista Nacional Km 1½ s/n, Santiago de Cuba 90400, Cuba
Yamile Heredia-Díaz
Pharmacy Department, Natural and Exacts Sciences Faculty, Oriente University, Avenida Patricio Lumumba s/n, Santiago de Cuba 90500, Cuba
Idelsy Chil-Núñez
Pharmacy Department, Natural and Exacts Sciences Faculty, Oriente University, Avenida Patricio Lumumba s/n, Santiago de Cuba 90500, Cuba
Jorge de la Vega
Toxicology and Biomedicine Centre (TOXIMED), University of Medical Science, Autopista Nacional Km 1½ s/n, Santiago de Cuba 90400, Cuba
Lianet Monzote
Department of Parasitology, Institute of Tropical Medicine “Pedro Kourí”, Apartado Postal No. 601, Marianao 13, La Habana 10400, Cuba
Margareth Maria de Carvalho Queiroz
Laboratory of Medical and Forensic Entomology, Instituto Oswaldo Cruz, IOC/FIOCRUZ, Rio de Janeiro 21040-360, RJ, Brazil
William N. Setzer
Research Network Natural Products against Neglected Diseases (ResNetNPND), 48149 Münster, Germany
Mosquitoes are one of the main vectors of many important diseases and their degree of resistance to chemical insecticides has increased. Nowadays, it has become crucial to identify novel plant larvicides with an eco-friendly impact. The components of essential oils from Croton linearis Jacq. (EO-Cl), Lantana involucrata L. (EO-Li), Ocimum sanctum var. cubensis M. Gómez. (EO-Os), and Zanthoxylum pistaciifolium Griseb. (syn. Zanthoxylum flavum subsp. pistaciifolium (Griseb.) Reynel (EO-Zp) were determined using gas chromatography-mass spectrometry (GC–MS) analysis. Larvicidal and adulticidal bioassays against Aedes aegypti, Anopheles albitarsis and Culex quinquefasciatus, were performed according to the World Health Organization standard methods. A high diversity of compounds was identified in the four oils, with a total of 152 compounds (33–70 components). EO-Cl, EO-Li, and EO-Os were classified as active against both insect forms, larvae and adults. Lantana involucrata showed the best results, with LC50 values from 33.8 to 41.7 mg/L. In most of the cases, it was not possible to associate the main compounds with the measured activity, supporting the hypothesis about probable synergistic interactions among major and minor compounds. The results indicate EO-Cl, EO-Os, and EO-Li as good eco-friendly insecticides with potential.
