Metabolic aspects of adoptive immunotherapy of tumors

Abstract

In wide number of approaches to treatment of cancer immunotherapy plays special role. This approach exploits capabilities of immune system to support genetic constancy of different cells and tissues of the organism. Immunotherapy is designed to induce tumor cell destruction by T-lymphocytes whose receptors can recognize peptides of mutant proteins complexed with the molecules of the major histocompatibility complex. In clinical practice T-lymphocytes can result in sustained and complete responses in patients whose cancers were resistant to available treatment options. Recent evidences suggest that efficiency of such therapy generally depends on metabolic properties of T-lymphocytes. A number of approaches allows modulate T-cell metabolism providing strategies to optimize activity of anti-tumor T-lymphocytes.

Keywords

• anti-tumor immunity
• glycolysis
• t-cell receptor
• immunological memory
• immunometabolism