Molecular Cancer (Jun 2007)

t(8;14;18): A 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia

  • Lai Yongrong,
  • Primanneni Suneeta,
  • Shimonov Josif,
  • Liu Delong,
  • Ahmed Tauseef,
  • Seiter Karen

DOI
https://doi.org/10.1186/1476-4598-6-35
Journal volume & issue
Vol. 6, no. 1
p. 35

Abstract

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Abstract Burkitt's lymphoma (BL) is a heterogeneous group of highly aggressive mature B-cell malignancies. It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene. It is typically associated with a t(8;14) translocation. Dual translocation of t(8;14) (c-myc) and t(14;18) (bcl-2) was reported to be associated with extremely poor prognosis. This study reports a novel t(8;14;18) triple translocation in two patients with Burkitt's lymphoma.