Nature Communications (Sep 2019)

K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation

  • Yong Tang,
  • Hailin Tu,
  • Jie Zhang,
  • Xueqiang Zhao,
  • Yini Wang,
  • Jun Qin,
  • Xin Lin

DOI
https://doi.org/10.1038/s41467-019-12033-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

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Receptor-interacting protein kinase 1 (RIPK1) is a critical regulator of cell death but its regulation is unclear. Here, the authors report that RIPK1 kinase activity is regulated by ubiquitination.