THE MODERN IMMUNOSUPPRESSIVE TACTICS AS A WAY FOR INDUCING OF TOLEROGENIC STRATEGY AFTER LIVER TRANSPLANTATION (ANALYSIS OF THE PROBLEM STATUS)

Abstract

In this article the necessity of working out of individual therapeutical immunosuppressive tactics was consi- dered. The authors believe that doses and schemes of used drugs must not prevent the immunity regulation. Immunosuppressive drugs must induce native mechanisms of immune tolerance and reparative regeneration for preventing of fibrotic processes in grafts (liver). For optimal effect of drug immunosuppression after clinical liver transplantation it was suggested to reveal tole- rogenic recipient’s groups and also to work out and use informative diagnostic and prognostic methods for value of individual level and power tolerance stability of recipients.

Keywords

• immunosuppressive therapy
• tolerance
• fibrosis at liver transplantation.