STUDY OF WOUND HEALING ACTIVITY OF A MEDICINAL PRODUCT «GMDP LYOPHILIZATE FOR PREPARATION OF SOLUTION FOR INJECTION» PRODUCTION JSC «PEPTEK» (RUSSIA) IN THE SCHEMES OF COMBINED ANTIBIOTIC-IMMUNE THERAPY ON THE MODEL OF INFECTED SKIN WOUNDS AND SOFT TISSUES IN RATS

Abstract

The results of the study of the wound healing activity of the drug «GMDP lyophilizate for solution for injection» are presented in the model of infected skin and soft tissue wound in rats in order to confirm the benefits of combined therapy of infected wounds with an antibiotic and the immunotherapeutic agent being tested in comparison with monotherapy with an antibiotic. The study used macroscopic, planimetric and histological methods. The advantages of the proposed combined therapy for the speed and completeness of wound cleansing and closure, including the intensity of epithelialization, the formation of granulation tissue, as well as the quality of granulation tissue, the degree of reduction of inflammatory changes, and lysis of the scabies are statistically reliable. In the control (intact) group the area of wounds decreased on average with speed 14,0±4,1 mm2/day, while in the «GMDP lyophilizate + Ceftriaxone» group this value was 25,1±4,7 mm2/day (significant difference from the control, p=0,0096).

Keywords

• gmdp (glucoseminylmuramildipeptidum)
• ceftriaxone
• specific activity
• purulent infected wounds
• therapy